An integrated approach combining experimental, informatics and energetic methods for solid form derisking of
Ghazala Sadiq1, Shubham Sharma2, Joanna S Stevens1
1The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK.
None:
The landscapes of observed and predicted three-dimensional crystal packing arrangements of small-molecule drug candidates can be complex. The possible appearance of a more thermodynamically stable solid form during drug development has led to the digital workflow of informatics-based risk assessments, named a Solid Form Health Check. Herein, we describe the use of a combined approach consisting of experiments, informatics together with energetic calculations in analysis of four competing polymorphs of PF-06282999, a myeloperoxidase (MPO) inhibitor with conformational flexibility and multiple plausible hydrogen bond networks. This combined approach offered a comprehensive understanding of the solid form structure, properties, and performance, ensuring robust solid form derisking and selection.
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