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Biological functions of the m6A reader YTHDF2 and its role in central nervous system disorders

Lili Song1, Huimin Liu1, Weiyu Yang1

  • 1School of Traditional Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, China.

Biochemical Pharmacology
|October 18, 2024
PubMed

Insights

N6-methyladenosine (m6A) modification is regulated by YTHDF2, a key protein influencing RNA metabolism. YTHDF2

Area of Science:

  • Molecular Biology
  • Epigenetics
  • Neuroscience

Background:

  • N6-methyladenosine (m6A) is a prevalent, reversible mRNA modification in eukaryotes.
  • YTH structural domain family protein 2 (YTHDF2) is a critical m6A reader, binding m6A-modified RNAs.
  • YTHDF2 influences RNA metabolism and cellular functions through diverse mechanisms.

Purpose of the Study:

  • To review the role of YTHDF2 in the pathogenesis of central nervous system (CNS) diseases.
  • To investigate the regulatory mechanisms of YTHDF2 in neurological disorder development.
  • To provide insights for targeted prevention and treatment of CNS diseases.

Main Methods:

  • Literature review of current research on YTHDF2 and CNS diseases.
  • Analysis of YTHDF2's upstream and downstream targets in disease pathogenesis.
  • Exploration of YTHDF2's regulatory roles in signaling pathways and gene expression.

Main Results:

  • YTHDF2 is implicated in the pathogenesis of various CNS diseases.
  • YTHDF2 regulates key signaling pathways and gene expression relevant to neurological disorders.
  • Understanding YTHDF2's targets is crucial for disease development.

Conclusions:

  • YTHDF2 plays a significant role in the development and progression of CNS diseases.
  • Targeting YTHDF2-mediated pathways offers potential therapeutic strategies for neurological disorders.
  • Further research into YTHDF2's mechanisms can advance the prevention and treatment of CNS conditions.
Keywords:
Alzheimer’s diseaseCentral nervous system diseasesParkinson’s diseaseYTHDF2m6A

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