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Oyster hydrolysate ameliorates UVB-induced skin dehydration and barrier dysfunction
Theodomir Dusabimana1, Jacques Karekezi2, Tatang Aldi Nugroho2
1Department of Pharmacology, Institute of Medical Sciences, Gyeongsang National University College of Medicine, Jinju 52727, Republic of Korea.
Abstract:
Ultraviolet (UV) exposure triggers skin aging primarily by disrupting skin barrier function, resulting in dry skin and wrinkle formation. Oyster hydrolysate (OH), as a functional food, has been reported for anti-cancer, anti-oxidant and anti-apoptotic effects. This study investigated the underlying mechanism of OH effect on UVB-induced skin aging in SKH1 hairless mice. Mice were exposed to UVB three times per week while they were fed with a normal diet or diet containing OH for 10 weeks. Additionally, a randomized, double-blind, and placebo-controlled clinical trial was performed to investigate the OH effect on human skin moisturizing to evaluate its efficacy and safety. UVB exposure increased parameters of skin aging; dehydration, transepidermal water loss, and macroscopic dorsal skin lesions. OH significantly reduced these features of skin aging. Histological analysis demonstrated that OH decreased skin epidermal and dermal thickness and collagen degradation induced by UVB. OH significantly reduced ROS production, suppressed macrophage activation and neutrophil infiltration, and downregulated pro-inflammatory cytokine production. OH improved skin barrier function by increasing the expression of filaggrin, aquaporin-3, and hyaluronic acid synthesis enzymes and promoting recovery from skin damage. Importantly, the results from a human clinical trial demonstrated that OH improved skin moisturization and integrity with no side effects. Taken together, OH supplementation ameliorates skin damage via anti-oxidant and anti-inflammatory properties and enhances skin hydration and barrier function. OH has a therapeutic potential for skin photoaging.
Insights
Oyster hydrolysate (OH) effectively combats UVB-induced skin aging by reducing wrinkles and improving hydration. This functional food demonstrates antioxidant and anti-inflammatory properties, enhancing skin barrier function and offering therapeutic potential for photoaging.
Area of Science:
- Dermatology
- Biochemistry
- Nutraceuticals
Background:
- Ultraviolet (UV) radiation is a primary driver of skin aging, causing dryness and wrinkles by impairing skin barrier function.
- Oyster hydrolysate (OH) is recognized for its antioxidant, anti-apoptotic, and anti-cancer properties.
Purpose of the Study:
- To investigate the protective mechanisms of oyster hydrolysate (OH) against UVB-induced skin aging in mice.
- To evaluate the efficacy and safety of OH for improving human skin moisturization through a clinical trial.
Main Methods:
- SKH1 hairless mice were exposed to UVB radiation and fed either a normal diet or a diet supplemented with OH for 10 weeks.
- Skin aging parameters, histological changes, oxidative stress markers, inflammatory responses, and skin barrier components were assessed.
- A randomized, double-blind, placebo-controlled clinical trial was conducted on human participants.
Main Results:
- UVB exposure led to skin dehydration, increased transepidermal water loss, and lesions, which were significantly reduced by OH.
- OH decreased epidermal and dermal thickness, mitigated collagen degradation, and reduced oxidative stress and inflammation.
- OH supplementation upregulated key skin barrier proteins (filaggrin, aquaporin-3) and hyaluronic acid synthesis, improving skin hydration and integrity.
Conclusions:
- Oyster hydrolysate (OH) ameliorates UVB-induced skin aging through potent antioxidant and anti-inflammatory effects.
- OH enhances skin hydration and barrier function, demonstrating significant therapeutic potential for managing skin photoaging.
- Clinical trials confirmed OH's efficacy in improving skin moisturization and integrity without adverse effects.
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