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Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
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The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
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Updated: Jun 10, 2025

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Micron-scale imaging using bulk ultrasonics.

Loheshwaran Chandran1, Mohamed Subair Syed Akbar Ali1, Bradley Bobbs2

  • 1Centre for Nondestructive Evaluation (CNDE), Indian Institute of Technology Madras, Chennai, 600036, India.

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|October 18, 2024
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Researchers achieved 50-micron resolution in bulk ultrasonics using novel micro-metalens technology. This breakthrough offers high-resolution material diagnostics at greater depths, surpassing traditional methods.

Keywords:
Acoustic microscopyMicro metamaterialPeriodic holey structuresRayleigh diffraction limitationSub-wavelength imaging

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Area of Science:

  • Materials Science
  • Acoustics
  • Nanotechnology

Background:

  • Bulk ultrasonics typically lacks high resolution for deep material diagnostics.
  • Existing electromagnetic techniques are costly and involve radiation.
  • Micro-fabrication offers potential for advanced ultrasonic applications.

Purpose of the Study:

  • To demonstrate unprecedented resolution in bulk ultrasonics.
  • To develop and characterize novel micro-fabricated metamaterial lenses.
  • To establish micro-metalens-enhanced ultrasound as a viable diagnostic tool.

Main Methods:

  • Development of silicon-based Fabry-Perot type metalenses with 10-micrometer holes.
  • Utilizing a custom micro-focal laser with sub-micron spot size for wave reception.
  • Implementing an innovative experimental setup with physics-based signal processing.

Main Results:

  • Achieved an extraordinary resolution of 50 microns for bulk ultrasonics.
  • Successfully demonstrated the performance of the novel micro-metalenses.
  • Overcame wave reception challenges for enhanced signal quality.

Conclusions:

  • Micro-metalens-enhanced ultrasound provides a high-resolution alternative for material diagnostics.
  • This technology enables deeper material analysis compared to conventional methods.
  • Offers a cost-effective and radiation-free approach for material inspection.