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Multinational epidemiological analysis of oral human papillomavirus incidence in 3,137 men

Racheal S Dube Mandishora1, Brittney L Dickey2, Wenyi Fan3

  • 1Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, Tampa, FL, USA.

Nature Microbiology
|October 18, 2024
PubMed

Insights

Men are at risk of acquiring oral human papillomavirus (HPV) infections throughout their lives. Catch-up vaccination could help reduce new oral HPV infections and prevent oropharyngeal cancer (OPC).

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Oncology

Background:

  • Oral human papillomavirus (HPV) infection is a known risk factor for oropharyngeal cancer (OPC).
  • Global incidence of OPC is rising, yet data on oral HPV infection prevalence remain scarce.
  • Understanding oral HPV epidemiology is crucial for public health interventions.

Purpose of the Study:

  • To analyze the incidence and risk factors of oral HPV infection in men.
  • To assess the long-term risk of acquiring oral HPV in a male population.
  • To inform potential vaccination strategies for preventing OPC.

Main Methods:

  • Observational epidemiological study involving 3,137 men from the US, Mexico, and Brazil (2005-2009).
  • Longitudinal follow-up for a median of 57 months to track new oral HPV infections.
  • Statistical analysis to determine incidence rates and associated risk factors for HPV acquisition.

Main Results:

  • The incidence rate of oral oncogenic HPV was 2.4 per 1,000 person-months.
  • Oral HPV incidence remained constant across age groups and throughout the study period.
  • Significant risk factors for oral HPV acquisition included alcohol consumption, having male sexual partners, increased lifetime female partners, performing oral sex, and higher education.

Conclusions:

  • Men face a persistent lifetime risk of acquiring oral HPV infections.
  • Identifying risk factors aids in targeted prevention strategies.
  • Catch-up HPV vaccination programs may be effective in reducing new infections and subsequent OPC cases.

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