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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
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Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

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Risk factors for Pseudomonas aeruginosa isolation in chronic obstructive pulmonary disease: a systematic review and

Yuyu Zhang1, Nini Zhang2, Tingting Li1

  • 1Department of General Practice, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi , 710032, China.

BMC Pulmonary Medicine
|October 18, 2024
PubMed
Abstract

Insights

Pseudomonas aeruginosa (PA) isolation in COPD patients is linked to poor outcomes. Nine risk factors, including prior antibiotic use and high BODE index, were identified, aiding early risk identification and improved patient prognosis.

Area of Science:

  • Pulmonary Medicine
  • Infectious Diseases
  • Clinical Epidemiology

Background:

  • Pseudomonas aeruginosa (PA) isolation in patients with chronic obstructive pulmonary disease (COPD) is associated with poorer prognosis.
  • Identifying risk factors for PA isolation is crucial for improving clinical outcomes in COPD patients.

Approach:

  • A systematic meta-analysis was conducted using data from PubMed, Embase, Web of Science, and CNKI (January 2003-September 2024).
  • Included were case-control and cohort studies assessing risk factors for PA isolation in COPD patients.
  • A random-effects model was used to calculate pooled adjusted odds ratios (paOR) and hazard ratios (paHR) with 95% confidence intervals (CI).

Key Points:

  • Thirteen studies with 25,802 participants were analyzed.
  • Significant risk factors identified include prior systemic steroid therapy, previous antibiotic treatment, high BODE index, low 6-min walking distance (<250 m), high CAT score (>20), hypoproteinemia, recent hospitalizations, bronchiectasis, and prior PA isolation.
  • Prior PA isolation showed the strongest association (paOR: 16.39; 95% CI: 7.65-35.10).

Conclusions:

  • Nine distinct risk factors significantly increase the likelihood of PA isolation in COPD patients.
  • These findings support early identification of high-risk individuals.
  • Targeted interventions based on these risk factors may reduce mortality and enhance clinical outcomes for COPD patients with PA isolation.
Keywords:
COPDMeta-analysisPseudomonas aeruginosaRisk factorsSystematic review

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