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Updated: Jun 10, 2025
Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
Published on: September 5, 2017
Laser-driven electron source suitable for single-shot Gy-scale irradiation of biological cells at dose rates
C A McAnespie1, P Chaudhary2, L Calvin1
1Centre for Light-Matter Interactions, School of Mathematics and Physics, <a href="https://ror.org/00hswnk62">Queen's University Belfast</a>, BT7 1NN, Belfast United Kingdom.
Abstract:
We report on the first systematic characterization of a tuneable laser-driven electron source capable of delivering Gy-scale doses in a duration of 10-20 ps in a single irradiation, thus reaching unprecedented dose rates in the range of 10^{10}-10^{12} Gy/s. Detailed characterization of the source indicates, in agreement with Monte Carlo simulations, dose delivery over cm-scale areas with a high degree of spatial uniformity. The results reported here confirm that a laser-driven source of this kind can be used for systematic studies of the response of biological cells to picosecond-scale radiation at ultrahigh dose rates.
