Search research articles

Related Concept Videos

Mechanism of Lamellipodia Formation

Mechanism of Lamellipodia Formation

Cells migrating in response to external stimuli form lamellipodia, which are thin membrane protrusions supported by a mesh of linked, branched, or unbranched actin filaments. These actin filaments interact with myosin motor proteins, creating the dynamic actomyosin complex within the cytoskeleton. Contractility, or the ability to generate contractile stress, is inherent to the actomyosin complex. It helps cells detect the stiffness of the surrounding ECM and exert contractile force for...

Actin Treadmilling

Actin Treadmilling

Actin filaments undergo polymerization and depolymerization from either end. The polymerization and depolymerization rates depend on the cytosolic concentration of free G-actins. The polymerization rate is generally higher at the plus or barbed end, while the depolymerization rate is higher at the minus or pointed end. At a steady state, critical concentration describes the concentration of free G-actin monomers at which the polymerization rate at the plus end is equal to that of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Author Correction: A mechanical ratchet drives unilateral cytokinesis.

Nature·2026

Same author

Phyllotaxis in a Keller-Segel model.

Physical review. E·2026

Same author

A mechanical ratchet drives unilateral cytokinesis.

Nature·2026

Same author

Tight junctions control lumen morphology via hydrostatic pressure and junctional tension.

Developmental cell·2024

Same author

Mechanical and biochemical feedback combine to generate complex contractile oscillations in cytokinesis.

Current biology : CB·2024

Same author

Mechanical positive feedback and biochemical negative feedback combine to generate complex contractile oscillations in cytokinesis.

bioRxiv : the preprint server for biology·2023

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 10, 2025

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

How the zebra got its stripes: Curvature-dependent diffusion orients Turing patterns on three-dimensional surfaces.

Michael F Staddon¹

¹<a href="https://ror.org/05hrn3e05">Center for Systems Biology Dresden</a>, Dresden 01307, Germany; <a href="https://ror.org/01bf9rw71">Max Planck Institute for the Physics of Complex Systems</a>, Dresden 01187, Germany; and <a href="https://ror.org/05b8d3w18">Max Planck Institute of Molecular Cell Biology and Genetics</a>, Dresden 01307, Germany.

Physical Review. E

|October 19, 2024

Summary

This study introduces a new mechanism for animal pattern formation using surface curvature to orient reaction-diffusion system patterns. This approach successfully orients stripes on models of zebras and cats, offering insights into developmental biology.

More Related Videos

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Published on: June 2, 2022

Determination of Aggregate Surface Morphology at the Interfacial Transition Zone ITZ

Determination of Aggregate Surface Morphology at the Interfacial Transition Zone ITZ

Published on: December 16, 2019

Related Experiment Videos

Last Updated: Jun 10, 2025

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Planar Gradient Diffusion System to Investigate Chemotaxis in a 3D Collagen Matrix

Published on: June 12, 2015

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Generation of Multicue Cellular Microenvironments by UV-Photopatterning of Three-Dimensional Cell Culture Substrates

Published on: June 2, 2022

Determination of Aggregate Surface Morphology at the Interfacial Transition Zone ITZ

Determination of Aggregate Surface Morphology at the Interfacial Transition Zone ITZ

Published on: December 16, 2019

Area of Science:

Mathematical Biology
Developmental Biology
Computational Modeling

Background:

Animals exhibit diverse patterns (stripes, spots) generated by biological processes.
Reaction-diffusion systems, like Turing models, simulate pattern formation.
Controlling pattern orientation in these models remains a challenge.

Purpose of the Study:

To propose a novel mechanism for orienting patterns in reaction-diffusion systems.
To investigate the role of surface geometry, specifically curvature, in pattern orientation.
To simulate and validate the proposed mechanism on animal models.

Main Methods:

Developed a reaction-diffusion model incorporating surface curvature.
Modified anisotropic diffusion rates based on local surface curvature.
Performed numerical simulations using models of zebra and cat patterns.

Main Results:

The model successfully recaptured the correct orientation of stripes on simulated animals.
Local surface curvature was shown to influence diffusion rates and global pattern formation.
Demonstrated robust pattern generation controlled by local geometric information.

Conclusions:

Surface curvature is a key factor in orienting reaction-diffusion patterns.
This model provides a mechanism for global pattern control using local geometric cues.
Offers an alternative to morphogen gradients for conveying shape and positioning information in development.