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Dual-Task Stroop Paradigm for Detecting Cognitive Deficits in High-Functioning Stroke Patients
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Post-stroke fatigue severity is associated with executive dysfunction in chronic stroke.

Chloe Carrick1,2, Andrea Kusec1,3, Nele Demeyere1,3

  • 1Department of Experimental Psychology, University of Oxford, Oxford, UK.

Neuropsychological Rehabilitation
|October 19, 2024
PubMed
Summary

Long-term fatigue after stroke is linked to executive functioning deficits. This study found that poorer executive function, not other cognitive domains, significantly predicted higher fatigue severity in chronic stroke survivors.

Keywords:
Chronic strokedomain-specific cognitionexecutive functioningfatigue

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Area of Science:

  • Neurology
  • Rehabilitation Medicine
  • Cognitive Neuroscience

Background:

  • Post-stroke fatigue is a prevalent and persistent issue, significantly impacting stroke survivors' quality of life.
  • Managing fatigue remains a critical unmet need for both patients and healthcare professionals in stroke recovery.
  • While cognitive impairments are linked to fatigue in early stroke recovery, their role in chronic stages (>2 years) is less understood.

Purpose of the Study:

  • To investigate the relationship between domain-specific cognitive functioning and self-reported fatigue severity in chronic stroke survivors.
  • To identify which cognitive domains are associated with persistent fatigue long after the initial stroke event.

Main Methods:

  • Cross-sectional observational study involving 105 chronic stroke survivors (mean age 72.92 years, 4.57 years post-stroke).
  • Cognitive assessments included attention, language, episodic memory, working memory, and executive functioning (set-shifting).
  • Fatigue severity was measured using the Fatigue Severity Scale.

Main Results:

  • Multiple linear regression analysis revealed that only poorer executive functioning was significantly associated with increased fatigue severity.
  • Deficits in attention, language, episodic memory, and working memory were not significantly linked to fatigue severity in this chronic cohort.
  • Executive functioning deficits emerged as the primary cognitive correlate of long-term post-stroke fatigue.

Conclusions:

  • Executive functioning deficits are a key hallmark of persistent fatigue in individuals long after stroke.
  • Targeting executive function impairments may be crucial for managing chronic fatigue in stroke survivors.
  • This finding highlights the importance of comprehensive cognitive assessment in the long-term rehabilitation of stroke patients experiencing fatigue.