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Taxonomic intestinal microbiota differences in Lewy body spectrum disease and cohabitant controls

Levi M Teigen1, Stuart J McCarter2, Zachary Ziegert3

  • 1Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN, 55108, USA.

Parkinsonism & Related Disorders
|October 19, 2024
PubMed
Abstract

Insights

Gut microbiome composition in dementia (LBD) and related disorders (iRBD) closely resembles that of cohabiting controls. These findings highlight the importance of using appropriate controls in microbiome research.

Area of Science:

  • Neuroscience
  • Microbiology
  • Genetics

Background:

  • Microbial dysbiosis is linked to neurodegenerative diseases.
  • Identifying causative or prognostic microbiome indicators is crucial.

Purpose of the Study:

  • To compare gut microbiome composition in symptomatic Lewy body dementia (LBD), idiopathic rapid eye movement sleep behavior disorder (iRBD), and controls.
  • To assess the impact of cohabiting versus non-cohabiting controls in microbiome studies.

Main Methods:

  • 16S rRNA amplicon sequencing was used.
  • Analyzed gut microbiome in 38 cases (27 LBD, 11 iRBD) and 39 cohabitant controls.
  • Included 19 non-cohabitant healthy controls (HCs) for comparison.

Main Results:

  • Gut microbiome composition was similar between LBD, iRBD, and cohabitant controls.
  • iRBD cases showed reduced Bacteroides compared to cohabitant controls.
  • Significant taxonomic differences were found between non-cohabitant HCs and cases.

Conclusions:

  • Minimal gut microbiome differences exist between LBD/iRBD patients and their cohabiting controls.
  • The study emphasizes the necessity of utilizing cohabiting controls in future gut microbiome research.

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