High arousal threshold is associated with metabolic syndrome in patients with obstructive sleep apnea

Obstructive sleep apnea (OSA) is associated with metabolic syndrome (MetS). OSA patients with high arousal threshold (ArTH) are less easy to arouse, which leads to more severe hypoxic events. We explored the relationship between high ArTH and MetS in patients with OSA.

We conducted a cross-sectional study of 112 patients with OSA (mean age 43.50 ± 11.64 years, 89.29 % male). High ArTH was based on an overnight polysomnography, and defined as none or one of the following conditions: apnea-hypopnea index (AHI) < 30 events/hour, minimum oxygen saturation > 82.5 %, or frequency of hypopnea events > 58.3 %. Metabolic syndrome and its components were defined according to the new International Diabetes Federation definition.

Among the 112 OSA patients, 51 (45.54 %) had MetS and 68 (60.71 %) had high ArTH. Logistic regression, after adjusting for confounders, showed that patients with high ArTH had higher odds for MetS (OR = 4.31, 95 % CI = 1.63-11.42, p = 0.003), central obesity (OR = 5.78, 95 % CI = 1.95-17.16, p = 0.002) and hypertriglyceridemia (OR = 2.84, 95 % CI = 1.11-7.28, p = 0.030) compared to patients with low ArTH. Furthermore, higher ArTH levels were associated with higher values for waist circumference (p-for-trend < 0.001), triglycerides (p-for-trend = 0.042), and systolic blood pressure (p-for-trend = 0.037). Moreover, patients with high ArTH had more apnea events and less hypopnea events.

High ArTH is associated with MetS in OSA patients. High ArTH is a marker of the severity of cardiometabolic comorbidity in OSA.