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Published on: June 12, 2020
Exploring the complex relationship between attention deficit hyperactivity disorder and the immune system: A
Jianbin Du1, Lin Fang2, Kunlun Dong3
1Department of Geriatric Psychiatry, The Affiliated Mental Health Center of Jiangnan University, Wuxi Central Rehabilitation Hospital, Wuxi, Jiangsu 214151, China.
Attention-deficit/hyperactivity disorder (ADHD) influences immune cell traits like monocytes and granulocytes. Certain immune cells, including B cells and myeloid-derived suppressor cells, are identified as risk or protective factors for ADHD.
Area of Science:
- Neuroimmunology
- Genetics
- Psychiatry
Background:
- Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder.
- Alterations in immune markers are observed in individuals with ADHD.
- The precise relationship between ADHD and the immune system requires further investigation.
Purpose of the Study:
- To investigate the causal relationship between ADHD and immune cell traits.
- To explore bidirectional associations between ADHD and immune system markers.
Main Methods:
- Bidirectional Mendelian randomization (MR) analysis was employed.
- Genome-wide association study (GWAS) summary data was utilized.
- The randomized inverse variance weighting (IVW) method was applied.
Main Results:
- ADHD was found to increase levels of myeloid dendritic cells, monocytes, and granulocytes.
- A specific B cell panel trait emerged as a risk factor for ADHD.
- Several immune cell traits, including CD14+ monocytes and myeloid-derived suppressor cells (MDSC), demonstrated protective effects against ADHD.
Conclusions:
- This study identified significant causal links between ADHD and various immune cell traits.
- The findings highlight complex interactions between ADHD and the immune system.
- Targeting identified immune risk and protective factors may aid ADHD prevention and treatment.
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