Related Experiment Video

Updated: Jun 10, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
07:24

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

1.7K

Epidemiologic profile of hemoglobinopathies in Benin

Selma Gomez1, Adjile Edjide Roukiyath Amoussa2, Edwige Dedjinou3

  • 1Centre de Prise en charge Médicale Intégrée du Nourrisson et de la Femme Enceinte atteints de Drépanocytose (CPMI-NFED), Benin; Laboratory of Biology and Molecular Typing in Microbiology, University of Abomey-Calavi, Benin.

Hematology, Transfusion and Cell Therapy
|October 19, 2024
PubMed

Insights

Sickle cell disease screening is crucial in Benin, revealing a high prevalence of hemoglobinopathies. Early detection through newborn screening and genetic counseling is vital for prevention.

Area of Science:

  • Hematology
  • Genetics
  • Public Health

Background:

  • Sickle cell disease is a major global inherited blood disorder, prioritized by the WHO in Africa.
  • Prevention strategies include newborn screening and genetic counseling for at-risk couples.
  • Understanding local prevalence is key to effective public health interventions.

Purpose of the Study:

  • To investigate the epidemiological profile of sickle cell disease and hemoglobinopathies in Benin.
  • To determine current prevalence rates of these conditions in the population.

Main Methods:

  • Quantitative electrophoresis was used to analyze hemoglobin profiles of 2910 participants.
  • Complete blood counts were performed on samples with abnormal hemoglobin results.

Main Results:

  • The study included 1528 males and 1382 females, with a mean age of 26 years.
  • Prevalence included Hb AS (21.7%), Hb AC (10.2%), Hb SS (3.1%), Hb SC (3.7%), and rare phenotypes (1.6%).
  • Abnormal hemoglobin carriers presented with normochromic normocytic anemia; only 12% knew their status.

Conclusions:

  • The study underscores the significant prevalence of hemoglobinopathies in Benin.
  • Highlights the critical need for widespread population screening programs.
  • Emphasizes the importance of early detection for disease management and prevention.
Abstract

Keywords:
MorbidityMortalityPreventionScreeningSickle cell disease

More Related Videos

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management05:35

Author Spotlight: Developing a Point-of-Care Hemoglobin Estimation Method for Anemia Management

Published on: January 19, 2024

719
Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry08:23

Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry

Published on: November 5, 2019

9.8K

Related Concept Videos

Hemoglobin01:24

Hemoglobin

Hemoglobin is a globular protein made up of four subunits. Two of these subunits are alpha chains, and the other two are beta chains. Each subunit contains a molecule of heme, which has an iron atom and can bind to oxygen. When an oxygen molecule binds to one heme group, it changes the shape of hemoglobin, making it easier for the other heme groups to bind oxygen as well.
When all four heme groups are bound to oxygen, the resulting molecule is called oxyhemoglobin. As a result, arterial blood...
3.4K
Disorders of Erythrocytes01:27

Disorders of Erythrocytes

Disorders of erythrocytes, or red blood cells (RBCs), include a range of conditions affecting their number, shape, or function.
Erythrocyte disorders can be broadly categorized into two main types: anemic and polycythemic conditions.
A low oxygen-carrying capacity of the blood due to the loss, lower production, or destruction of erythrocytes is termed anemia. Hemorrhagic anemia, for example, occurs when bleeding from an external wound or internal ulcer reduces erythrocyte counts.
On the other...
890
Pedigree Analysis01:35

Pedigree Analysis

Overview
84.0K
Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
17.4K
Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
34.0K
Gene Families01:57

Gene Families

Gene families consist of groups of genes proposed to have originated from a common ancestor. Typically these arise through events in which a gene or genes are mistakenly duplicated during cell division. Unlike their parent genes (which are subject to selection pressure to maintain function), these gene copies do not need to preserve their sequences and may evolve at a relatively faster rate.
Occasionally these regions can be adapted to take on new roles within the organism, becoming novel genes...
8.8K