Related Experiment Video

Updated: Jun 10, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

13.5K

Renal involvement in solid cancers: epidemiological, clinical and histological characteristics study of 154

Victor Gueutin1,2, Aurore Cardineau3, Alexis Mathian4

  • 1Service de néphrologie-dialyse-transplantation CHU de CAEN, Côte de Nacre, Caen, France. gueutin-v@chu-caen.fr.

BMC Nephrology
|October 19, 2024
PubMed
Abstract

Insights

Cancer patients often experience kidney damage from treatments. Kidney biopsies reveal common chronic lesions and drug toxicity, highlighting the need for specialized onconephrology care.

Area of Science:

  • Oncology
  • Nephrology
  • Pathology

Background:

  • Onconephrology addresses cancer and kidney disease management.
  • Accurate kidney histology is crucial but often lacking.
  • Anatomopathological data are vital for complex patient care.

Purpose of the Study:

  • To analyze clinicobiological and histological data from kidney biopsies in cancer patients.
  • To identify common kidney pathologies and etiological diagnoses in onconephrology.

Main Methods:

  • Retrospective analysis of 154 patients with active cancer undergoing kidney biopsy (KB) between 2014-2020.
  • Evaluation of clinicobiological and histological findings.

Main Results:

  • Common findings include proteinuria (72%), acute kidney injury (61%), and hypertension (38%).
  • Histology showed high rates of interstitial fibrosis (74%) and tubular atrophy (55%).
  • Nephrotoxicity from anticancer drugs was the primary cause (56%), with immunotherapy and anti-VEGF agents frequently implicated.

Conclusions:

  • Kidney toxicity of cancer treatments is the leading cause of kidney disease in onconephrology.
  • Multiple underlying mechanisms and associated diagnoses complicate kidney damage management.
  • Chronic histological lesions are prevalent, emphasizing the importance of kidney biopsy.
Keywords:
ImmunotherapyKidney pathologyNephrotoxicityOnconephrologyThrombotic microangiopathy

More Related Videos

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

Published on: March 4, 2022

2.2K
Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

7.7K

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
Nephrons01:10

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.2K
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
2
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...