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Silk Composite-Based Multifunctional Pellets for Controlled Release.

Sushma Indrakumar1, Sriram Bharath Gugulothu1, Akshat Joshi1

  • 1Department of Materials Engineering, Indian Institute of Science, Bangalore, 560012, India.

Macromolecular Bioscience
|October 20, 2024
PubMed
Summary
This summary is machine-generated.

A new silk/bioceramic composite drug delivery system enhances chronic wound healing. This multifunctional platform offers antioxidant and antibacterial properties for point-of-care treatments, improving patient outcomes.

Keywords:
bioceramicschronic woundsdrug delivery systempoint‐of‐caresilk fibroin

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Chronic wounds pose significant clinical challenges due to infection and inflammation.
  • Existing point-of-care treatments are limited by complex fabrication and lack essential healing properties.
  • Calcium sulfate hemihydrate (CSH) platforms offer rapid fabrication but lack antioxidant and antibacterial functions.

Purpose of the Study:

  • To engineer a multifunctional drug delivery platform for chronic wound management.
  • To develop a silk/bioceramic composite for point-of-care applications.
  • To enhance healing properties by incorporating antioxidant and antibacterial functionalities.

Main Methods:

  • Engineered a tannic acid (TA)-silk fibroin (SF) complex as an additive for CSH cement.
  • Fabricated silk/bioceramic-based composite pellets for drug delivery.
  • Incorporated the TA-SF complex into CSH to create multifunctional pellets.
  • Evaluated antioxidant activity, antibacterial efficacy, and in vivo toxicity in a rodent model.

Main Results:

  • Composite pellets demonstrated a 7.5-fold increase in antioxidant activity compared to neat CSH.
  • Prolonged antibacterial efficacy was observed for up to 13 days.
  • Subcutaneous implantation showed no signs of local or systemic toxicity in a rodent model.
  • Optimized composition and fabrication for potential market translation.

Conclusions:

  • The developed multifunctional silk/bioceramic system offers enhanced antioxidant and antibacterial properties for chronic wound healing.
  • This platform provides a promising solution for personalized, point-of-care treatments.
  • The composite pellets have potential applications in wound beds and bone cavities for therapeutic delivery.