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Author Spotlight: Dendritic Cells Maturation Using Sialidases-Based Enzymatic Treatment of the Cell Surface
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Published on: October 20, 2023

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Sialic acid and Siglec receptors in tumor immunity and immunotherapy

Natalia Rodrigues Mantuano1, Heinz Läubli2

  • 1Laboratory for Cancer Immunotherapy, Department of Biomedicine, University of Basel, Switzerland.

Seminars in Immunology
|October 20, 2024
PubMed

Immunotherapy, including immune checkpoint inhibition, has transformed cancer therapy in recent years, providing new and potentially curative options for patients with even advanced disease. However, only a minority of patients achieve long-lasting remissions, and resistance to immune checkpoint inhibition is common. Recently, the sialic acid-Siglec axis has been proposed as a new immune checkpoint that could overcome resistance to current immunotherapy options. In this review, we summarize the current preclinical knowledge about the role of the sialic acid-Siglec interaction in immune suppression in cancer and discuss potential approaches to block this inhibitory pathway to enhance anti-cancer immunity.

Keywords:
Cancer immunotherapyGlycosylationImmune checkpointMyeloid cell

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