Related Experiment Video
Updated: Jun 10, 2025
Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
Published on: May 6, 2020
Structure-function of cartilage in osteoarthritis: An ex-vivo correlation analysis between its structural,
Luisa de Roy1, Graciosa Quelhas Teixeira1, Jonas Schwer1
1Institute of Orthopedic Research and Biomechanics, Center for Trauma Research, Ulm University Medical Center Ulm, Germany.
Abstract:
Healthy articular cartilage is characterized by extremely low friction and high compressive stiffness. This dual-functionality is tailored by its biphasic structure, whereby a fluid phase interacts with the extracellular matrix. Osteoarthritis (OA) causes structural changes, thereby altering the biomechanical and frictional properties. How the structural and functional properties of human cartilage are associated with OA remain unknown. To address this, we identified relationships between structural parameters, viscoelastic and frictional properties of degenerated human cartilage through correlation analyses. We found that cartilage friction was mainly influenced by its microscopic structure, while the viscoelastic properties were also related to the macroscopic structure. The viscoelastic and frictional properties displayed a weak correlation. These findings provide insights into the interplay between cartilage structure and its functional properties in OA, which might provide a basis for advancements in diagnosing and treating degenerated human cartilage. STATEMENT OF SIGNIFICANCE: Osteoarthritis causes changes in the cartilages biphasic structure, thereby affecting functionality by altered biomechanical and frictional properties. Currently a cartilage-preserving therapeutic option remains lacking, because the disease is not fully understood. In our correlation analyses, we investigated relationships between the structural, the viscoelastic and frictional properties of degenerated human cartilage. We found that cartilage friction was particularly dependent on the microscopic structure, while the viscoelastic properties also correlated with the macroscopic structure. The frictional properties displayed only a weak dependency with the viscoelastic properties. These new insights into the structure-function and inter-functional relationships may provide new options to advance the diagnosis and treatment of degenerated cartilage.
