The whole life journey and destination of microplastics: A review

Recent reports indicate that ubiquitous microplastics (MPs) in the environment can infiltrate the human body, posing significant health risks and garnering widespread attention. However, public understanding of the intricate processes through which microplastics are transferred to humans remains limited. Consequently, developing effective strategies to mitigate the escalating issue of MPs pollution and safeguard human health is still challenging. In this review, we elucidated the sources and dynamic migration pathways of MPs, examined its complex interactions with other pollutants, and identified primary routes of human exposure. Subsequently, the events and alterations of gut microbiota, gut microbiota metabolism, and intestinal barrier after MPs enter the gut of organisms are unclosed. Additionally, it highlighted the ease with which MPs translocate from the intestine to other organs along with their biological toxicities. Finally, we also emphasized the knowledge gaps in the current research field and proposes future research directions. This review aims to enhance public awareness regarding microplastic pollution and provide valuable references for forthcoming research endeavors as well as policy formulation related to this pressing issue.