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Updated: Jun 10, 2025

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Engineered mRNAs With Stable Structures Minimize Double-stranded RNA Formation and Increase Protein Expression

Qianshan Qin1, Huayuan Yan2, Weixiang Gao2

  • 1State Key Laboratory of Cardiology and Medical Innovation Center, Shanghai East Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University), Ministry of Education, Orthopaedic Department of Tongji Hospital, Frontier Science Center for Stem Cell Research, Bioinformatics Department, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Suzhou Abogen Biosciences Co., Ltd., Suzhou, Jiangsu 215123, China.

Journal of Molecular Biology
|October 20, 2024
PubMed

Keywords:
RNA immunogenicityRNA purificationdouble-stranded RNAin vitro transcriptionmessenger RNA

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