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Updated: Jul 21, 2026

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
Published on: January 15, 2017
Use of a Stroke Alert Protocol and Outcomes at a Quaternary Children's Hospital
Benjamin Africk1, Ingrid Luo2, Andrew Silverman1
1Division of Child Neurology, Department of Neurology, Stanford School of Medicine, Stanford, CA.
Insights
Implementing a pediatric stroke alert protocol improved diagnostic efficiency, significantly reducing code-to-image times for in-hospital pediatric stroke alerts. Out-of-hospital alerts did not show similar improvements.
Area of Science:
- Pediatric Neurology
- Emergency Medicine
- Healthcare Quality Improvement
Background:
- Pediatric stroke diagnosis requires rapid assessment and imaging.
- Standardized alert protocols aim to improve diagnostic efficiency and patient outcomes.
- In-hospital (IH) and out-of-hospital (OH) stroke alerts may have different activation and response characteristics.
Purpose of the Study:
- To evaluate the impact of a pediatric stroke alert protocol on diagnostic efficiency.
- To compare the characteristics of IH versus OH pediatric stroke alerts.
- To assess changes in code-to-image (CTI) times after protocol implementation.
Main Methods:
- Retrospective review of pediatric stroke alerts (October 2016-October 2022).
- Analysis of code-to-image (CTI) times using generalized linear models.
- Comparison of demographic, clinical, and imaging characteristics between IH and OH alerts.
Main Results:
- Overall mean CTI time decreased by 4.56 minutes/year (P=.007).
- IH alerts showed a significant decrease in CTI time (8.33 minutes/year), while OH alerts showed an increase (1.90 minutes/year).
- CTI improved for CT/CTA and non-sedated MRI, but not for sedated MRI.
Conclusions:
- A pediatric stroke alert protocol led to improved CTI times for in-hospital alerts.
- Out-of-hospital pediatric stroke alerts did not demonstrate similar improvements in diagnostic efficiency.
- Further optimization may be needed for out-of-hospital pediatric stroke alert pathways.
Objective:
To assess for improvement in diagnostic efficiency following implementation of an institutional pediatric stroke alert protocol at a quaternary children's hospital, and to compare characteristics of in-hospital (IH) and out-of-hospital (OH) stroke alert activations.
Study Design:
We retrospectively reviewed data from pediatric stroke alerts called for children between age 1 month and 21 years of age at our quaternary children's hospital between October 2016 and October 2022 after implementation of an institutional stroke alert protocol. Generalized linear models assessed code-to-image (CTI) time over the study period, with and without interaction terms for alert location. Demographic, clinical, and imaging characteristics between IH and OH alerts were compared using Fisher's exact test or Mann-Whitney U test.
Results:
Of 206 total stroke activations, 129 (62.6%) occurred IH and 77 (37.4%) occurred OH. Overall mean CTI time decreased by 4.56 minutes per year (P = .007) after adjusting for confounders. The association between year and mean CTI time was significantly stronger for IH alerts (decrease of 8.33 minutes/year) compared with OH alerts (increase of 1.90 minutes/year). Subgroup analyses showed that CTI for computed tomography (CT) ± CT angiography and magnetic resonance imaging (MRI) without sedation improved, although CTI time for MRI with sedation did not change over time. IH/OH divergent trends were consistent for CT ± CTA and nonsedated MRI.
Conclusions:
After implementation of a pediatric stroke alert protocol, we observed a steady and significant improvement in CTI times for IH, but not OH alerts.
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