Prognosis and factors related to anti-VEGF therapy in patients with retinal vein occlusion and concomitant carotid artery disease
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View abstract on PubMed
Summary
This summary is machine-generated.Retinal vein occlusion (RVO) patients with carotid artery disease show lower anti-VEGF treatment effectiveness. Poor baseline vision, retinal layer disruption, and higher red blood cell distribution width (RDW) predict worse outcomes in these patients.
Area Of Science
- Ophthalmology
- Vascular Medicine
- Retinal Diseases
Background
- Retinal vein occlusion (RVO) is a significant cause of vision loss.
- Carotid artery disease is a potential comorbidity affecting vascular health.
- Anti-vascular endothelial growth factor (anti-VEGF) therapy is a standard treatment for RVO.
Purpose Of The Study
- To investigate the treatment outcomes of anti-VEGF therapy in RVO patients with and without concurrent carotid artery disease.
- To identify risk factors influencing visual prognosis in RVO patients with concomitant carotid artery disease.
Main Methods
- Retrospective analysis of 177 RVO patients receiving anti-VEGF treatment.
- Patients were categorized into two groups: with (Group A) and without (Group B) carotid artery disease.
- Multivariate logistic regression was used to identify prognostic factors.
Main Results
- Group A (with carotid artery disease) demonstrated significantly lower treatment effectiveness compared to Group B (P < 0.001).
- Group A exhibited higher average age and platelet distribution width.
- Key predictors of poor visual prognosis in Group A included poor baseline best-corrected visual acuity (BCVA), disorganization of retinal inner layers (DRIL), external limiting membrane (ELM) disruption, and elevated red blood cell distribution width (RDW).
Conclusions
- Concomitant carotid artery disease negatively impacts anti-VEGF treatment efficacy in RVO patients.
- Baseline BCVA, DRIL, ELM disruption, and RDW are critical prognostic indicators for RVO patients with coexisting carotid artery disease.
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