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Updated: Jun 10, 2025

Dynamic Contrast Enhanced Magnetic Resonance Imaging of an Orthotopic Pancreatic Cancer Mouse Model
Published on: April 18, 2015
Optimized versus conventional trigger threshold for pancreatic phase image acquisition using dual-energy CT at
Yoshifumi Noda1,2, Hiromi Koyasu3, Avinash Kambadakone4
1Massachusetts General Hospital, Boston, USA. noda.yoshifumi.g9@f.gifu-u.ac.jp.
Purpose:
To evaluate the impact of optimized trigger threshold on 40-keV pancreatic phase images acquired with a dual-energy CT (DECT) protocol.
Methods:
A cohort of 69 consecutive participants (median age, 72 years) undergoing a pancreatic protocol DECT examination between September to December 2021 were prospectively randomized into two protocols: conventional trigger threshold of 100 HU (Group A, n = 34) and optimized trigger threshold of 30 HU (Group B, n = 35). Pancreatic phase image acquisition was performed with fixed delay of 20 s from the trigger threshold. Two radiologists assessed the 40-keV pancreatic phase images for scan timing adequacy using a binary scale (adequate or inadequate). The proportions of these classifications were compared in the two groups using the Fisher's test.
Results:
The median times to achieve the aortic attenuation of 30 HU and 100 HU were 16.3 s and 22.3 s in Group A, respectively, and was 17.8 s for 30 HU in Group B. The median time difference from 30 HU to 100 HU was 4.5 s in Group A. The scan timing adequacies of pancreatic phase images were classified as adequate (50.0% and 74.3%) or inadequate (50.0% and 25.7%) in Group A and Group B (P = 0.049).
Conclusion:
An optimized trigger threshold of 30 HU allows consistent acquisition of adequate pancreatic phase images compared to the conventional trigger threshold of 100 HU for pancreatic protocol DECT at 40-keV which might lead to improved pancreatic lesion conspicuity.
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