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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Skeletal Reorganization Emanated via the Course of Heterocyclic N1-N2 Bond Cleavage: Electrosynthetic Approach
Saiful Islam1, Dwaipayan Das1, Rahul Dev Mandal1
1Department of Chemistry, University of Calcutta, 92, A.P.C. Road, Kolkata 700009, W B, India.
Abstract:
A unified method toward the synthesis of functionalized diazepines and quinazolines through reorganization of the molecular skeleton has been devised. The process is indulged by electrical energy via a domino N1-N2 bond cleavage followed by concomitant ring closing, initiating from cinnolines and indazoles as designed precursors. Additionally, an intermolecular ring homologation has also been established to synthesize densely functionalized dihydroquinazolines from 2,3-diaryl-indazoles and acetonitrile involving the same electrochemical strategy.
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