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Updated: Jun 16, 2026

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

738

Cerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage

Julia Buchmayer1, Renate Fuiko1, Patric Kienast2

  • 1Comprehensive Center for Pediatrics, Department of Pediatrics and Adolescent Medicine, Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Medical University of Vienna, Vienna, Austria.

Developmental Medicine and Child Neurology
|October 21, 2024
PubMed

Insights

Cerebellar haemorrhage (CBH) and atrophy in extremely preterm infants with intraventricular haemorrhage (IVH) significantly impact neurodevelopment. Higher CBH grade correlates with worse cognitive and motor outcomes at two years.

Area of Science:

  • Neonatal neurology
  • Pediatric neurodevelopment
  • Cerebral imaging

Background:

  • Intraventricular haemorrhage (IVH) is a common complication in extremely preterm infants.
  • Cerebellar injury, including haemorrhage (CBH) and atrophy, can occur alongside IVH.
  • The long-term neurodevelopmental impact of CBH and cerebellar atrophy in this population requires further investigation.

Purpose of the Study:

  • To investigate the impact of cerebellar haemorrhage (CBH) and atrophy in infants born extremely preterm with intraventricular haemorrhage (IVH) on neurodevelopment at 2 years of age.
  • To determine if CBH and cerebellar atrophy are independent predictors of neurodevelopmental outcomes.
  • To explore the relationship between the severity of CBH and neurodevelopmental outcomes.

Main Methods:

  • Retrospective case-control study of infants born at <28 weeks' gestation with IVH over 10 years.
  • Magnetic resonance imaging (MRI) used to assess CBH and cerebellar size.
  • Multivariable regression analysis applied to evaluate neurodevelopmental outcomes at 2 years' corrected age.

Main Results:

  • 67% of 103 infants had CBH (median grade 1).
  • CBH was significantly associated with impaired cognitive and motor outcomes, and cerebral palsy.
  • Cerebellar atrophy (29.1%) correlated with worse outcomes, while increased cerebellar size was linked to improved motor development.

Conclusions:

  • Infants with extremely preterm IVH and CBH show significant cognitive and motor impairments.
  • Developmental delay severity correlates with CBH grade.
  • Findings can aid in predicting long-term outcomes and parental counseling.
Abstract

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