Related Experiment Video

Updated: Jun 10, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

8.6K

8-Aminopurines: A Promising New Direction for Purine-Based Therapeutics

Edwin K Jackson1,2, Stevan P Tofovic1,2, Yuanyuan Chen1,3

  • 1Department of Pharmacology and Chemical Biology (E.K.J., S.P.T., Y.C., L.A.B.), University of Pittsburgh School of Medicine, Pittsburgh, PA.

Hypertension (Dallas, Tex. : 1979)
|October 21, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
guanosinehypertensioninosinepurine nucleoside phosphorylase

More Related Videos

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.6K
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

10.6K

Related Experiment Videos

Last Updated: Jun 10, 2025

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides
08:46

Regioselective O-Glycosylation of Nucleosides via the Temporary 2',3'-Diol Protection by a Boronic Ester for the Synthesis of Disaccharide Nucleosides

Published on: July 26, 2018

8.6K
A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
09:04

A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products

Published on: September 9, 2016

10.6K
Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

10.6K

Related Concept Videos

Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

9
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
9

Articles linked to this work by shared authors, journal, and citation graph.

Functional Roles of Adenosine A2B and A3 Receptor Subtypes in the Bladder of Male Rats With A2B Receptor Deletion or Bladder Outlet Obstruction.

Neurourology and urodynamics·2026

Purinergic activity of circulating extracellular vesicles associates with disease progression in melanoma.

Oncoimmunology·2026

Rationale for the Use of 8-Aminoguanine for the Management of Cystitis.

International journal of urology : official journal of the Japanese Urological Association·2026

8-Aminoguanine protects against paclitaxel-induced neural degeneration and mechanical allodynia.

JCI insight·2026

CD39 polymorphism enables lung thrombosis in sickle cell disease.

Nature communications·2026

Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice.

Journal of cellular and molecular medicine·2025

Neurovascular Signaling in the Perivascular Space: Biophysical Principles and Disruption in Hypertension.

Hypertension (Dallas, Tex. : 1979)·2026

Intrarenal Determinants of GFR Decline During Loop Diuretic Therapy.

Hypertension (Dallas, Tex. : 1979)·2026

TSP-1 Endothelial Signaling Impairs Brain Angiogenesis in Preeclampsia.

Hypertension (Dallas, Tex. : 1979)·2026

Follistatin Alleviates Vascular Dysfunction by Reducing Oxidative Stress and Promoting Browning in Perivascular Adipose Tissue.

Hypertension (Dallas, Tex. : 1979)·2026

Glycemia, Insulin Sensitivity Markers and Arterial Stiffness: The Framingham Heart Study.

Hypertension (Dallas, Tex. : 1979)·2026

Impact of High Dietary Salt on Neurovascular and Cognitive Functions.

Hypertension (Dallas, Tex. : 1979)·2026

Direct Initiation of Long-Acting Cabotegravir Plus Rilpivirine in People with HIV and Suboptimal Virologic Suppression: A Randomized Trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2026

A Metabolism-Oriented Strategy for Systematic Analysis of the Pharmacological Material Basis of Classic Traditional Chinese Medicine Formulas: Taking Wuao Sanzi Decoction as an Example.

Journal of separation science·2026

Comparative effectiveness of apalutamide-, abiraterone-, and enzalutamide-based doublets in mHSPC.

BJU international·2026

Simulation-Based Evaluation of Busulfan Sampling Strategies in Adults and Adolescents Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.

Journal of clinical pharmacology·2026

An isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedure for the quantification of piperacillin in human serum and plasma.

Clinical chemistry and laboratory medicine·2026

Factors influencing pharmacovigilance practices among health care professionals in lower-middle-income countries: a scoping review.

JBI evidence synthesis·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us