Antimicrobial Properties of Secondary Metabolites Produced by Halomonas sp.: A Halophilic Bacterium

Aim It is unknown whether the halotolerant bacterium Halomonas sp. produces a range of secondary metabolites with antimicrobial qualities. In the past few years, there has been a growing interest in the biotechnological capability of halophilic bacteria for the production of antimicrobial compounds. Materials and methods The current review intended to assess the antibacterial and antifungal properties of microbial metabolites, explicitly those produced as secondary metabolites by a putative halophilic bacterium. First, phenotypic and genotypic identification were used to identify and confirm the obtained potent halophilic bacterium as Halomonas sp., and its antioxidant properties and biological compatibility were studied. Results The extracellular metabolites that were obtained exhibit a moderation zone of inhibition against 11 mm of Staphylococcus aureus, 12 mm of Pseudomonas aeruginosa, and 11 mm of Candida albicans. The optimal inhibitory concentration for S. aureus and P. aeruginosa is 256 µg/mL, while the minimum inhibitory concentration (MIC) for C. albicans is 128 µg/mL. The antioxidant property of crude metabolites indicates that 100% scavenging at 512 µg/mL, and the blow at 256 µg/mL, are not reasonable levels of antioxidant activity. Conclusion Secondary metabolites appear to be highly biologically compatible, as there is no hemolytic activity at any of the tested concentrations. According to the study, Halomonas sp.'s secondary metabolites could be a source for the synthesis of novel antimicrobial compounds.