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Updated: Jun 10, 2025
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.4K
Tumour Budding in Oral Squamous Cell Carcinoma: A Narrative Review
Sonali Jakkulwar1, Sunita Vagha1, Minakshi Chaudhary2
1Pathology, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, IND.
Cureus
|October 21, 2024
Summary
Tumour budding, a marker of invasive behaviour in oral squamous cell carcinoma (OSCC), indicates a higher risk of metastasis and poorer survival. Understanding tumour budding is crucial for personalized OSCC treatment strategies.
Area of Science:
- Oncology
- Pathology
Background:
- Tumour budding is an emerging prognostic factor in oral squamous cell carcinoma (OSCC).
- It reflects the invasive behaviour of the tumour, impacting patient outcomes.
Purpose of the Study:
- To provide a comprehensive overview of tumour budding's role in OSCC.
- To synthesize current research and clinical findings on tumour budding in OSCC.
Main Methods:
- Narrative review of existing literature.
- Analysis of correlations between tumour budding and histopathological features.
- Evaluation of methods for assessing tumour budding and associated challenges.
Main Results:
- Tumour budding is associated with increased local invasion and lymph node metastasis.
- Higher tumour budding correlates with poorer overall survival in OSCC patients.
- Tumour budding shows potential as a key marker for aggressive OSCC disease.
Conclusions:
- Tumour budding is a significant prognostic factor in OSCC.
- Standardized assessment of tumour budding is needed for clinical application.
- Further research can enhance the use of tumour budding in personalized OSCC treatment.
Keywords:
cancer progressionhistopathologyoral squamous cell carcinomaprognostic markerstumour buddingtumour microenvironmentMore Related Videos
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