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Updated: Jun 10, 2025

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

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Influences on the Hematopoietic Stem Cell Niche

Weiyuan Wang1,2, Timothy J Brown3, Brian M Barth2,4

  • 1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta GA 30322 USA.

Scibase Hematology & Blood Disorders
|October 21, 2024
PubMed

Hematopoietic stem cells (HSCs) are supported by the bone marrow microenvironment to maintain normal production of blood cells. The niche may be considered an "ecosystem" that support the function of HSCs and other supportive cells. Alterations in the bone marrow niche are commonly observed in hematologic malignancies. Here, we review recent insights into the location and the molecular and cellular components of the bone marrow niche. Moreover, we discuss how the niche interacts with HSCs to drive the pathogenesis of hematopoietic malignancies. Overall, a better understanding of the influences on the HSC niche may drive therapeutic development targeting defective and aberrant hematopoiesis.

Keywords:
CXCL12G-CSFacute myeloid leukemiaangiogeninbone marrowhematopoietic stem cellsmesenchymal stem cellsmetabolismmicroenvironmentmyelodysplastic syndromenichestem cell factorthrombopoietin

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