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  11. Clinicodemographic And Computed Tomography Scan Findings Associated With Thyroid Gland Invasion Among Patients With Laryngeal Squamous Cell Carcinoma

Clinicodemographic and Computed Tomography Scan Findings Associated with Thyroid Gland Invasion among Patients with Laryngeal Squamous Cell Carcinoma

Anna Kristina M Hernandez1,2, Cindy Pearl J Sotalbo3,4, Antonio Marlo P Nievera3

  • 1Department of Otolaryngology - Head and Neck Surgery, Philippine General Hospital, University of the Philippines Manila.

Acta Medica Philippina
|October 21, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Preoperative CT scans showing cricoid cartilage invasion or thyroid gland involvement are linked to thyroid gland extension in laryngeal squamous cell carcinoma (SCC). These findings suggest thyroidectomy may improve resection margins for affected patients.

Area of Science:

  • Otorhinolaryngology
  • Oncology
  • Radiology

Background:

  • Laryngeal squamous cell carcinoma (SCC) poses challenges in determining tumor extent.
  • Accurate preoperative assessment of tumor invasion is crucial for effective surgical planning.
  • The role of CT scan findings in predicting thyroid gland involvement in laryngeal SCC requires further investigation.

Purpose of the Study:

  • To determine the association between preoperative CT scan findings (thyroid cartilage invasion, cricoid cartilage invasion, paraglottic space involvement) and tumor extension to the thyroid gland on final histopathology in laryngeal SCC patients.
  • To evaluate the predictive value of specific CT findings for thyroid gland involvement.
  • To inform surgical decision-making, particularly regarding the extent of thyroidectomy.

Main Methods:

Keywords:
cancer of larynxcarcinomasquamous cellthyroidectomy

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  • Retrospective review of CT scans and histopathology reports from 63 laryngeal SCC patients who underwent total laryngectomy with thyroidectomy.
  • Two independent radiologists blinded to histopathology results assessed CT scans for cartilage invasion, paraglottic space, and thyroid gland involvement.
  • Statistical analysis included Fisher's exact test, Cramer's V, phi coefficient, and odds ratio to assess associations (p<0.05 considered significant).

Main Results:

  • Thyroid cartilage erosion/invasion was noted on CT in 63.4% and histopathology in 58.7% of patients.
  • Significant associations were found between cricoid cartilage involvement on CT and thyroid gland involvement on histopathology (p=0.032).
  • Thyroid gland involvement on CT scan was significantly associated with thyroid gland involvement on final histopathology (p=0.018, OR=13).

Conclusions:

  • Preoperative CT findings of cricoid cartilage involvement and thyroid gland involvement are significantly associated with thyroid gland involvement on final histopathology in laryngeal SCC.
  • These CT findings may indicate a higher risk of thyroid gland extension, suggesting that thyroidectomy could be beneficial for achieving adequate resection margins.
  • The study highlights the importance of detailed CT evaluation in planning surgical management for laryngeal SCC.