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In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

In vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Published on: August 4, 2011

Activatable fluorescent probes for atherosclerosis theranostics.

Yuanyuan You¹, Chengwei Tang², Songling Lin¹

¹School of Pharmacy, Guangdong Medical University, Dongguan 523808, China.

|October 21, 2024

Summary

This summary is machine-generated.

Developing precise fluorescent probes targeting the atherosclerotic microenvironment offers new hope for early atherosclerosis (AS) detection and treatment. These advanced probes enable imaging-guided therapy for better cardiovascular event prevention.

Keywords:

Biomaterials Cardiovascular medicine Medical imaging Optical imaging Optical materials

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Area of Science:

Biomedical Engineering
Molecular Imaging
Cardiovascular Research

Background:

Atherosclerosis (AS) onset is insidious with atypical early symptoms, often leading to late-stage diagnosis and fatal cardiovascular events.
Current diagnostic and therapeutic strategies for AS require significant improvement in precision and efficiency.

Purpose of the Study:

To review activatable fluorescent probes designed for the atherosclerotic microenvironment.
To explore the correlation between microenvironment changes, probe activation, and fluorescence signals.
To highlight progress in AS theranostics and future outlook for imaging-guided therapy.

Main Methods:

Review of scientific literature on activatable fluorescent probes for atherosclerosis.
Analysis of probe design principles based on atherosclerotic microenvironment biomarkers.
Summarization of probe performance metrics (sensitivity, specificity, signal-to-noise ratio).

Main Results:

Activatable fluorescent probes demonstrate high sensitivity and specificity for AS detection.
Probes exhibit tunable fluorescence responses to specific biomarkers within the atherosclerotic microenvironment.
Emerging theranostic applications show promise for integrated diagnosis and treatment.

Conclusions:

Activatable fluorescent probes are powerful tools for precise AS diagnosis and therapy.
Targeting the atherosclerotic microenvironment enhances probe efficacy and specificity.
Further development is crucial for advancing imaging-guided precise AS treatment strategies.