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Recurrence potential of thin primary melanomas.

P L Naruns, J A Nizze, A J Cochran

    Cancer
    |February 1, 1986
    PubMed
    Summary
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    Metastases from thin melanomas, though infrequent, can occur. Careful long-term follow-up and prompt investigation of swollen lymph nodes are crucial for all melanoma patients, regardless of initial tumor depth.

    Area of Science:

    • Oncology
    • Dermatology
    • Surgical Oncology

    Background:

    • Thin primary melanomas (Clark level < IV, Breslow depth < 0.76 mm) are generally considered low-risk.
    • However, the potential for metastasis in these cases requires further investigation.

    Purpose of the Study:

    • To analyze the incidence and characteristics of metastases in patients with thin primary melanomas.
    • To identify risk factors and outcomes associated with metastasis in this patient group.

    Main Methods:

    • Retrospective review of 649 patients with thin primary melanomas treated at UCLA between 1971 and 1985.
    • Analysis of demographic, clinical, and pathological data for 36 patients who developed metastases.

    Main Results:

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  • 36 of 649 patients (5.5%) with thin melanomas developed metastases.
  • Metastases were more common in men (3:2 ratio) and originated most frequently on the trunk (44%).
  • 85% of re-examined lesions showed regression; 78% of metastases were to regional lymph nodes, with 15 patients disease-free at 99 months median follow-up.

    • Conclusions:

    • Metastases from thin melanomas, while uncommon, do occur and can be fatal.
    • Long-term surveillance and prompt evaluation of adenopathy are essential for patients with thin melanomas.