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Study of Time-Resolved Dynamics in Turbid Medium Using a Single-Cavity Dual-Comb Laser.

Binbin Zhang¹, Christopher Phillips², Esteban Venialgo Araujo¹

¹Department of Precision and Microsystems Engineering, Delft University of Technology, Mekelweg 2, Delft 2628 CD, The Netherlands.

ACS Photonics

|October 21, 2024

Summary

This study introduces a dual-comb laser system for noninvasive optical measurement of cerebral blood flow (CBF). The new method accurately measures tissue optical properties and differentiates blood flow dynamics at various depths.

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Area of Science:

Biomedical Optics
Medical Imaging
Laser Spectroscopy

Background:

Noninvasive optical techniques like diffusing-wave spectroscopy and near-infrared spectroscopy are used for cerebral blood flow (CBF) measurement.
A key challenge is accurately measuring CBF at a specific depth, avoiding superficial tissue interference.

Purpose of the Study:

To present a novel, simple approach using dual-comb lasers for simultaneous measurement of optical properties and dynamic properties.
To enable depth-resolved analysis of multilayer dynamics for improved CBF measurements.

Main Methods:

Utilized a dual-comb laser system to simultaneously measure absorption coefficient (μa) and reduced scattering coefficient (μs').
Employed the system to differentiate dynamic properties from various depths within tissue.

Main Results:

The dual-comb laser system successfully measured tissue optical properties and dynamic properties.
The system demonstrated the capability to differentiate dynamics from various depths, crucial for multilayer analysis.

Conclusions:

The presented dual-comb laser approach offers a simple yet effective method for noninvasive optical measurement of CBF.
This technique enhances specificity for deep tissue measurements by mitigating superficial layer interference, improving CBF assessment.