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  7. Oncology And Carcinogenesis
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  11. D-dimer As A Predictive Biomarker Of Response To Chemotherapy In Patients With Metastatic Breast Cancer

D-dimer as a Predictive Biomarker of Response to Chemotherapy in Patients With Metastatic Breast Cancer

Lubana Alkhoder1, Maher Salamoon2, Maher Saifo2,3

  • 1Department of Biochemistry and Microbiology, Faculty of Pharmacy, Al Baath University, Homs, Syrian Arab Republic.

Biomarker Insights
|October 21, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

D-dimer levels can predict chemotherapy response in metastatic breast cancer patients. Decreased D-dimer indicates treatment effectiveness, while increased levels suggest disease progression, aiding in monitoring treatment efficacy.

Area of Science:

  • Oncology
  • Hematology
  • Biochemistry

Background:

  • Tumor-induced coagulation is a known factor in cancer progression and metastasis.
  • D-dimer, a fibrin degradation product, shows correlation with prognosis in various cancers.

Purpose of the Study:

  • To evaluate D-dimer as a predictive and monitoring indicator for chemotherapy response in metastatic breast cancer (MBC).

Main Methods:

  • Prospective study involving 76 MBC patients and 25 primary breast cancer patients.
  • Plasma D-dimer levels measured before and after chemotherapy.
  • Receiver Operating Characteristic (ROC) curve analysis to determine D-dimer cut-off values and predictive ability.

Main Results:

  • D-dimer levels significantly decreased in patients with partial response and stable disease.
Keywords:
D-dimerchemotherapymetastatic breast cancerpredictive biomarker

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  • A marked increase in D-dimer levels was observed in patients with disease progression.
  • ROC analysis confirmed D-dimer's ability to discriminate chemotherapy response, with higher levels correlating with progressive disease.

    • Conclusions:

    • Plasma D-dimer serves as a valuable predictive and monitoring marker for chemotherapy response in metastatic breast cancer.
    • D-dimer levels can help assess treatment efficacy and detect disease progression.
    response