Aspiration cytology of neuroblastoma. Light and electron microscopic correlations

Fine-needle aspiration biopsy (FNAB) smears from 16 cases of neuroblastoma are reviewed, and various cytomorphologic features helpful in diagnosing this tumor are described. Cytoplasmic processes were present in ten cases, and pseudorosettes in three cases. Electron microscopic study of FNAB samples revealed that all diagnostically important features, such as cell processes, neurosecretory granules, and synaptic cell junctions, could be recognized. These findings indicate that FNAB studied by light and electron microscopy is an effective method for diagnosing neuroblastoma.