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Updated: Jun 10, 2025

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
The effects of digoxin on heart failure mortality and re-admission in a single center cross-sectional study
Mahsa Behnemoon1, Zahra Borumandkia2
1Department of Cardiology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Introduction:
Mortality benefit of digoxin prescription in patients suffering from heart failure has been questioned many time. We evaluated these effects among admitted symptomatic heart failure patients.
Methods:
We retrospectively divided our patients into two groups: group A (n=205) were digoxin prescribed, and group B (n=96) were digoxin naïve patients. Both groups' medical records were gathered for one year, and the study endpoints were compared between the two groups.
Results:
The mean age was 62.3±12.1 years and 54.8 % were male. All-cause mortality and readmission occurred in 26.7% and 31.7% of individuals, respectively, without significant differences between the two groups. However, in subgroup analysis, there was a significant relationship between in-hospital mortality and the presence of cardiovascular risk factors.
Conclusion:
Digoxin might increase in-hospital mortality in patients with underlying cardiovascular risk factors.
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