Related Experiment Video
Updated: Jun 10, 2025
11:55
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip System at Single Protein Resolution
Published on: August 16, 2016
11.7K
Pore Network Modeling of Intraparticle Transport Phenomena Accompanied by Chemical Reactions
A Fathiganjehlou1, E A J F Peters1, K A Buist1
1Multiphase Reactors Group, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Postbus, 5600 MB Eindhoven, The Netherlands.
Industrial & Engineering Chemistry Research
|October 21, 2024
Summary
A new 3D pore network model (PNM) simulates reaction-diffusion in spherical catalysts. This advanced model accounts for heat transfer and realistic boundary conditions, improving catalyst performance analysis.
Area of Science:
- Chemical Engineering
- Computational Modeling
- Catalysis Science
Background:
- Reaction-diffusion phenomena are crucial in porous catalysts.
- Accurate modeling of catalyst particles is essential for process optimization.
- Existing models often simplify particle geometry and boundary conditions.
Purpose of the Study:
- To introduce a novel 3D pore network model (PNM) for simulating reaction-diffusion in spherical catalyst particles.
- To incorporate coupled heat transfer into the particle-scale PNM.
- To enable the application of realistic, non-uniform boundary conditions.
Main Methods:
- Generated a 3D particle geometry by packing microspheres to represent porosity and tortuosity.
- Extracted a pore-network representation from the generated geometry.
- Constructed a PNM for diffusion-reaction and heat conduction.
Main Results:
- The developed PNM successfully models reaction-diffusion with and without heat transfer.
- The model can handle realistic 3D non-uniform surface boundary conditions.
- Analyzed internal concentration profiles and reaction effectiveness.
Conclusions:
- The particle-scale PNM provides a more realistic simulation of catalytic processes.
- This approach enhances the understanding of catalyst behavior under complex conditions.
- The model is valuable for optimizing catalyst design and packed-bed reactor performance.
Related Concept Videos
01:17Pore Transport and Ion-Pair Transport
377
Pore transport and ion-pair formation are critical mechanisms for the absorption and distribution of drugs in the body.
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
377
01:07Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
32
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion,...
A recent model describes pravastatin's hepatobiliary excretion,...
32
01:44Introduction to Membrane Traffic
7.0K
The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
7.0K
01:09Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
276
Various dissolution theories provide insight into the factors that influence the dissolution rate. Danckwerts' Model suggests that turbulence, rather than a stagnant layer, characterizes the dissolution medium at the solid-liquid interface. In this model, the agitated solvent contains macroscopic packets that move to the interface via eddy currents, facilitating the absorption and delivery of the drug to the bulk solution. The regular replenishment of solvent packets maintains the...
276
01:44The Significance of Membrane Transport
23.9K
The transport of solutes across the cell membrane is essential for metabolic processes, like maintaining cell size and volume, generating the action potential, exchanging nutrients and gases, etc. Membrane transport can be either passive or active. It can be simple diffusion, facilitated, or mediated transport aided by transport proteins such as transporters and channels.
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
Transporters facilitate either an active or passive movement of solutes. They can allow a single-molecule transport down its...
23.9K
00:57Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
67
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
67