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Published on: July 5, 2017
Correlation Between Intrinsic Capacity and Muscle Strength and Quality in Older Patients with Cardiovascular Disease:
Xiyan Yu1, Difei Wu2, Fangzhou Li3
1The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People's Republic of China.
Insights
Cardiovascular disease patients show reduced intrinsic capacity (IC), muscle strength, and quality. Early recognition of IC decline in older adults with CVD is crucial for intervention.
Area of Science:
- Gerontology
- Cardiology
- Muscle Physiology
Background:
- Cardiovascular disease (CVD) is a leading global cause of mortality.
- High muscle mass is linked to reduced CVD incidence and mortality.
- Intrinsic capacity (IC) decline is increasingly recognized as a factor in older adults' health.
Purpose of the Study:
- To explore the relationship between declining intrinsic capacity (IC), muscle strength, and muscle quality in older patients with cardiovascular disease (CVD).
- To provide a method for early recognition of IC decline in older adults with CVD.
Main Methods:
- Cross-sectional study of 475 older individuals.
- Comprehensive geriatric assessment (CGA) and bioelectrical impedance analysis (BIA).
- Statistical analysis including t-tests, Mann-Whitney tests, and ROC curve analysis to determine cutoff values.
Main Results:
- CVD patients exhibited significantly lower IC compared to non-CVD patients.
- Age, Fried score, and GDS-5 increased with IC decline severity.
- Activities of Daily Living (ADL), Mini-Mental State Examination (MMSE), Mini Nutritional Assessment-Short Form (MNA-SF), SARC-Calf, waist circumference, and muscle quality decreased with IC decline.
Conclusions:
- Patients with cardiovascular disease (CVD) and impaired intrinsic capacity (IC) demonstrated lower hand grip strength and muscle quality compared to those with retained IC.
- Established cutoff values for hand grip strength, waist circumference, and muscle quality can aid in identifying IC decline in older adults with CVD.
Background:
Cardiovascular disease (CVD) has become the leading cause of death worldwide. High muscle mass can reduce the incidence and mortality of CVD. In recent years, increasing attention has been given to the relationship between intrinsic capacity (IC) and CVD. This study aims to explore the relationship between the decline of IC, muscle strength, and muscle quality in older patients with CVD, providing a new method and basis for early recognition of IC decline in the older adults.
Methods:
This cross-sectional study included 475 older individuals from communities in Zhejiang. General data were collected, and a comprehensive geriatric assessment (CGA) was conducted. Participants with CVD were divided into three groups: IC retention, IC impairment, and IC significantly impaired. Bioelectrical impedance analysis (BIA) measurements were completed. Student's t-test or non-parametric tests (Mann-Whitney) were used to analyze the correlation between IC and muscle-related indicators. The best cutoff values were obtained using ROC curve analysis.
Results:
Compared to non-CVD patients, CVD patients were older, more educated, and had higher rates of polypharmacy and comorbidity. IC decreased more significantly in CVD patients. Age (P=0.001), Fried (P=0.024), and GDS-5 (P=0.002) increased with the severity of IC decline. ADL (P=0.002), MMSE (P=0.000), MNA-SF (P=0.000), SARC-Calf (P=0.026), waist circumference (P=0.037), and muscle quality (P=0.010) decreased with the decline in IC. When IC decreased, the cutoff values for hand grip strength, waist circumference, and muscle quality were 25.45 kg, 72.55 cm, and 3.05, respectively. When IC decreased significantly, the cutoff values were 17.15 kg, 71.55 cm, and 2.28, respectively.
Conclusion:
The results of this study showed that in patients with CVD, the hand grip strength and muscle quality of patients with IC injury were lower than those of patients with IC retention.
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