Observations by G-banding in benign odontogenic tumors

The G-banding patterns in five cultured benign odontogenic tumors are described. Abnormal stem sideline karyotypes were observed in two tumors, whereas the remaining three tumors had a normal stemline. The latter cases, however, contained different types of variant cells, often showing deviations of nonrandom character. The results are discussed in relation to chromosomal findings in other benign tumor types and, briefly, in relation to oncogenes. A stepwise evolutionary pattern, which might be common to all benign tumor types, is suggested.