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The change of FeNO is correlated with asthma control and lung function

Yanmin Gao1, Zhenyu Li2, Nengshun Wu1

  • 1Department of Pediatrics, the Eighth People's Hospital of Wuxi, Wuxi, China.

Heliyon
|October 21, 2024
PubMed

Insights

Budesonide/Formoterol Inhalation Powder Mist (B/FIPM) effectively reduces fractional exhaled nitric oxide (FeNO) and improves lung function in children with asthma. Changes in FeNO levels after treatment predict patient prognosis and correlate with lung function outcomes.

Area of Science:

  • Pediatric Pulmonology
  • Allergy and Immunology
  • Respiratory Medicine

Background:

  • Asthma is a common chronic respiratory disease in children.
  • Fractional exhaled nitric oxide (FeNO) is a biomarker of airway inflammation.
  • Assessing FeNO changes can provide insights into treatment efficacy and disease prognosis.

Purpose of the Study:

  • To investigate FeNO changes post-treatment in pediatric asthma patients.
  • To determine the association between FeNO changes and asthma prognosis.
  • To explore the correlation between FeNO changes and lung function recovery.

Main Methods:

  • 144 children with asthma were enrolled and treated with Budesonide/Formoterol Inhalation Powder Mist (B/FIPM).
  • FeNO levels were measured at baseline and after treatment.
  • Outcomes were assessed based on asthma control (well-controlled vs. partly controlled) and lung function after 1 year.

Main Results:

  • B/FIPM therapy significantly reduced FeNO levels and eosinophil counts, improving pulmonary function (P < 0.01).
  • Well-controlled asthma showed decreased FeNO after 1 week, while partly controlled asthma demonstrated sustained FeNO reduction after 2 weeks (P < 0.01).
  • A positive change in FeNO (ΔFeNO >0) was associated with a higher proportion of well-controlled outcomes in patients with initial FeNO ≤35 ppb (P = 0.042).

Conclusions:

  • B/FIPM is effective for reducing FeNO and eosinophils, and improving lung function in pediatric asthma.
  • Post-treatment FeNO changes serve as a predictive marker for asthma prognosis.
  • FeNO dynamics correlate with post-treatment lung function in children with asthma.
Abstract

Keywords:
AsthmaBudesonide/Formoterol Inhalation Powder MistFractional exhaled nitric oxide (FeNO)Lung functionPrognosisRespiratory

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