Prognostic value of pan immune-inflammation value in patients undergoing unprotected left main coronary artery...

Area of Science:

• Cardiology
• Interventional Cardiology
• Inflammation Biomarkers

Background:

• Left main coronary artery (LMCA) disease is a critical condition requiring revascularization.
• Percutaneous coronary intervention (PCI) is a common treatment for LMCA disease.
• Identifying long-term prognostic factors is crucial for managing patients post-PCI.

Purpose of the Study:

• To investigate the long-term prognostic value of inflammatory parameters, specifically Pan Immune-Inflammation Value (PIV) and Systemic Immune-Inflammation Index (SII), in patients undergoing unprotected LMCA PCI.
• To identify independent predictors of major adverse cardiac events (MACE) after LMCA PCI.

Main Methods:

• Retrospective, observational study of 121 patients undergoing unprotected LMCA PCI.
• Primary endpoint: MACE (all-cause death, repeat revascularization, myocardial infarction).
• Analysis of inflammatory markers (PIV, SII) and other clinical/procedural factors.

Main Results:

• PIV and SII were identified as independent predictors of MACE (p=0.045 and p=0.048, respectively).
• Other significant predictors included age, ejection fraction, creatinine, shock presentation, and residual SYNTAX score.
• PIV exhibited a slightly stronger predictive capability for MACE compared to SII.

Conclusions:

• PIV and SII are significant independent predictors of MACE in patients undergoing unprotected LMCA PCI.
• These inflammatory markers can aid in risk stratification for long-term outcomes.
• PIV may offer a marginal advantage over SII in predicting MACE in this patient cohort.