Related Experiment Video
Updated: Apr 13, 2026
Interactome-Seq: A Protocol for Domainome Library Construction, Validation and Selection by Phage Display and Next Generation Sequencing
Published on: October 3, 2018
Comprehensive phage display viral antibody profiling using VirScan: potential applications in chronic immune-mediated
Jed Valentiner Shrewsbury1,2, Evangelin Shaloom Vitus3, Adam Leslie Koziol3
1Faculty of Medicine, Imperial College London, London, United Kingdom.
None:
Phage immunoprecipitation sequencing (PhIP-Seq) is a high-throughput platform that uses programmable phage display for serology. VirScan, a specific PhIP-Seq library encoding viral peptides from all known human viruses, enables comprehensive quantification of past viral exposures. We review its use in immune-mediated diseases (IMDs), highlighting its utility in identifying viral exposures in the context of IMD development. Finally, we evaluate its potential for precision medicine by integrating it with other large-scale omics data sets.
