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Related Experiment Videos

A possible etiological role for ascorbate in calculi formation.

A H Chalmers, D M Cowley, J M Brown

    Clinical Chemistry
    |February 1, 1986
    PubMed
    Summary
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    Recurrent kidney stone formers show higher urinary oxalate and lower ascorbate levels. Ascorbate administration boosts oxalate production, particularly in the gut, for these individuals.

    Area of Science:

    • Biochemistry
    • Urology
    • Nutritional Science

    Background:

    • Recurrent kidney stone formers exhibit altered urinary profiles, including elevated oxalate and reduced ascorbate.
    • Understanding the metabolic pathways of oxalate is crucial for managing calcium stone disease.

    Purpose of the Study:

    • To investigate the relationship between ascorbate (vitamin C) and oxalate metabolism in recurrent calcium stone formers.
    • To determine the site of enhanced oxalate production from ascorbate in these patients.

    Main Methods:

    • Comparative analysis of urinary oxalate and ascorbate levels in recurrent stone formers versus normal individuals.
    • Administration of ascorbate (oral and intravenous) to assess its impact on oxalate production.

    Main Results:

    Related Experiment Videos

    • Recurrent stone formers demonstrated significantly higher urinary oxalate and lower urinary ascorbate excretions.
    • Ascorbate administration led to enhanced oxalate production in recurrent stone formers compared to controls.
    • Evidence suggests the gut is the primary site for this increased oxalate generation from ascorbate.

    Conclusions:

    • Altered ascorbate metabolism contributes to increased oxalate production in recurrent calcium stone formers.
    • The gut plays a significant role in the enhanced conversion of ascorbate to oxalate in susceptible individuals.
    • These findings may inform dietary or therapeutic strategies for preventing calcium oxalate stones.