A multi-scale feature extraction and fusion-based model for retinal vessel segmentation in fundus images

In response to the challenge of low accuracy in retinal vessel segmentation attributed to the minute nature of the vessels, this paper proposes a retinal vessel segmentation model based on an improved U-Net, which combines multi-scale feature extraction and fusion techniques. An improved dilated residual module was first used to replace the original convolutional layer of U-Net, and this module, coupled with a dual attention mechanism and diverse expansion rates, facilitates the extraction of multi-scale vascular features. Moreover, an adaptive feature fusion module was added at the skip connections of the model to improve vessel connectivity. To further optimize network training, a hybrid loss function is employed to mitigate the class imbalance between vessels and the background. Experimental results on the DRIVE dataset and CHASE_DB1 dataset show that the proposed model has an accuracy of 96.27% and 96.96%, sensitivity of 81.32% and 82.59%, and AUC of 98.34% and 98.70%, respectively, demonstrating superior segmentation performance.