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Waist-height Ratio Highlights Detrimental Risk For Olanzapine Associated Weight Gain Earlier Than Body Mass Index.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Waist-height Ratio Highlights Detrimental Risk For Olanzapine Associated Weight Gain Earlier Than Body Mass Index.

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Waist-height ratio highlights detrimental risk for olanzapine associated weight gain earlier than body mass index.

Ibrahim Mohammed Badamasi^1,2, Abiola Tajudeen³, Shakirat D Owolabi⁴

¹Department of Anatomy, Pharmacogenomics and Pharmacometabolomics Unit, Faculty of Basic Medical Sciences, College of Health Sciences, Bayero University Kano, Kano, Nigeria.

International Journal of Adolescent Medicine and Health

|October 21, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Waist-height ratio (WHtR) is more sensitive than body mass index (BMI) for detecting adiposity in schizophrenia patients on olanzapine. WHtR identifies more individuals needing weight management to prevent cardio-metabolic risks.

Keywords:

body mass index (BMI)obesity olanzapine schizophrenia

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Area of Science:

Metabolic Health
Psychiatric Pharmacology
Anthropometry

Background:

Schizophrenia patients on olanzapine are at high risk for cardio-metabolic complications.
Early identification of adiposity is crucial for intervention and risk mitigation.

Purpose of the Study:

To compare the sensitivity of body mass index (BMI) and waist-height ratio (WHtR) in identifying adiposity.
To assess which measure is better for initiating interventions to prevent cardio-metabolic risks in schizophrenia patients treated with olanzapine.

Main Methods:

A descriptive cross-sectional study comparing schizophrenia patients on olanzapine with healthy controls.
Measurement and comparison of key anthropometric parameters, including BMI and WHtR.

Main Results:

waist-height ratio (WHtR)

Schizophrenia patients exhibited significantly higher rates of abnormal BMI and WHtR compared to controls.
WHtR identified 64.7% of patients with concerning weight changes, compared to 43.3% identified by BMI.
WHtR detected an additional 21.4% of patients who could benefit from weight management guidance.

Conclusions:

Waist-height ratio (WHtR) is a more sensitive indicator of adiposity in schizophrenia patients on olanzapine.
WHtR is a valuable tool for monitoring and managing cardiometabolic risks in this vulnerable population.