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Updated: Jun 9, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Electrochemical Ferrier Rearrangement of Glycals
Chun Qi1, Giulio Goti1, Andrea Sartorel1
1Department of Chemical Sciences, University of Padova, Via Francesco Marzolo 1, 35131 Padova, Italy.
Abstract:
The Ferrier rearrangement (FR) is a well-documented reaction that relies on strong acids or oxidants to convert glycals into unsaturated glycosyl derivatives. In this work, we introduce an electrochemical variant of the FR, offering a broad substrate compatibility. Various nucleophiles and glycal derivatives afford 2,3-unsaturated glycosyl derivatives in high yields with excellent diastereoselectivities. This sustainable method promises to expand the electrochemistry applications in sugar chemistry.
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