Overcoming limitations and advancing the therapeutic potential of antibody-oligonucleotide conjugates (AOCs): Current

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Updated: Jun 9, 2025

Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction
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Genetic Encoding of a Non-Canonical Amino Acid for the Generation of Antibody-Drug Conjugates Through a Fast Bioorthogonal Reaction

Published on: September 14, 2018

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Jinlan Jiao1, Yun Qian2, Yinhua Lv3

  • 1Division of Breast Surgery, Department of General Surgery, Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China.

Pharmacological Research
|October 21, 2024
PubMed

Insights

Antibody-oligonucleotide conjugates (AOCs) offer a novel precision medicine approach by targeting disease-causing proteins to regulate gene expression. This targeted therapy shows promise for advanced cancer treatment, overcoming challenges in precision oncology.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Rising cancer incidence necessitates advanced precision medicine strategies.
  • Antibody-drug conjugates (ADCs) represent a successful targeted therapy approach.
  • Antibody-oligonucleotide conjugates (AOCs) emerge as a novel therapeutic modality.

Purpose of the Study:

  • To review the mechanism and components of antibody-oligonucleotide conjugates (AOCs).
  • To explore the application of AOCs in tumor therapy.
  • To address the challenges and future directions of AOCs in precision oncology.

Main Methods:

  • Review of existing literature on AOCs.
  • Analysis of AOC mechanisms for targeted gene regulation.
  • Discussion of AOC components and their role in therapy.

Main Results:

  • AOCs selectively target and modulate disease-causing proteins.
  • AOCs offer a unique approach to regulating gene expression in cancer cells.
  • Key challenges include manufacturing, endosomal escape, and immune response.

Conclusions:

  • AOCs represent a significant advancement in precision oncology.
  • Further research is needed to overcome challenges and optimize AOCs for cancer treatment.
  • AOCs hold potential for treating cancers driven by genetic mutations and abnormal protein expression.
Keywords:
Antibody-drug conjugatesAntibody-oligonucleotide conjugatesPrecision medicineTumor therapysiRNA

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