Micelle-Assisted C(sp2)-H Functionalization for C-Se and C-X Bond Formation in the Aqueous Medium
Abhinay S Chillal1, Chandani Maurya1, Umesh A Kshirsagar1
1Department of Chemistry, Indian Institute of Technology Indore, Khandwa Road, Indore 453552, India.
Abstract:
An environmentally sustainable, versatile, and cost-effective approach for C-Se and C-X (X = I, Br, and Cl) bond formation through C-H functionalization assisted by micellar catalysis in water is developed. The reaction utilizes a minimum amount of diorganyl diselenides and potassium halides for the respective functionalizations. The present protocol was suitable for scale-up synthesis, which directly provided the desired selenylated products without the need for chromatographic purification, in sufficient purity. The aqueous micellar catalysis system was reusable for up to 5 reaction cycles without compromising the reaction yield.
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