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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

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Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
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Bioavailability Enhancement: Drug Permeability Enhancement01:27

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After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
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Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells
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Demystifying the Potential of Embelin-Loaded Nanoformulations: a Comprehensive Review.

Layba Noor1, Abdul Hafeez2, Md Azizur Rahman1

  • 1Faculty of Pharmacy, Integral University, Lucknow, 226026, India.

AAPS Pharmscitech
|October 21, 2024
PubMed
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Embelin (EMB), a natural anti-inflammatory and anticancer compound, faces bioavailability challenges. Nanoformulations significantly enhance its therapeutic potential for various diseases.

Keywords:
Bioavailability improvementEmbelinNanostructured lipid carriersPolymeric nanoparticlesTargeted delivery

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Area of Science:

  • Natural Product Chemistry
  • Nanotechnology
  • Pharmacology

Background:

  • Phytoconstituents offer safer therapeutic alternatives with improved patient compliance.
  • Embelin (EMB), derived from Embelia ribes, exhibits potent anti-inflammatory and anticancer properties.
  • Poor water solubility and low oral bioavailability limit Embelin's clinical utility.

Purpose of the Study:

  • To review Embelin nanoformulations for enhanced therapeutic efficacy.
  • To analyze various nanocarrier systems and preparation methods for Embelin.
  • To discuss the physicochemical and preclinical potential of Embelin-based nanomedicines.

Main Methods:

  • Comprehensive literature search on Embelin nanoformulations.
  • Analysis of nanocarrier types including liposomes, nanoparticles, and micelles.
  • Evaluation of preparation techniques such as thin film hydration and nanoprecipitation.

Main Results:

  • Diverse nanoformulations (50-345 nm) improve Embelin's characteristics.
  • Detailed discussion of drug entrapment, release, and in vivo studies.
  • Exploration of dual-drug approaches and patent landscape for clinical translation.

Conclusions:

  • Nanoencapsulation is crucial for overcoming Embelin's limitations.
  • Embelin nanoformulations show significant promise for treating inflammatory and cancerous conditions.
  • Further research and clinical translation of Embelin nanomedicines are warranted.