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Enhancing parathyroid preservation in papillary thyroid carcinoma surgery using nano-carbon suspension
De-Xin Lin1,2, Xin-Bin Zhuo3,4, Yin Lin5
1Department of Hepatobiliary, Pancreatic and Splenic Surgery, Ningde Clinical Medicine of Fujian Medical University, Ningde, 352100, China. ldx556@126.com.
Scientific Reports
|October 21, 2024
Summary
Nano-carbon suspension aids thyroid cancer surgery by improving parathyroid gland preservation and reducing complications. This technique enhances surgical precision, leading to better patient outcomes in papillary thyroid carcinoma treatment.
Area of Science:
- Oncology
- Surgical Innovation
- Biomaterials
Background:
- Papillary thyroid carcinoma (PTC) treatment often involves total thyroidectomy with cervical lymph node dissection.
- Ensuring parathyroid gland preservation and minimizing postoperative complications are critical surgical goals.
Purpose of the Study:
- To evaluate the clinical significance of nano-carbon suspension in total thyroidectomy with cervical lymph node dissection for PTC.
- To assess nano-carbon suspension's efficacy in enhancing parathyroid gland preservation, reducing complications, and improving surgical precision.
Main Methods:
- Retrospective analysis of 219 PTC patients undergoing total thyroidectomy with cervical lymph node dissection.
- Comparison between an experimental group (n=107) using nano-carbon suspension and a control group (n=112) without.
- Analysis of demographics, surgical parameters, postoperative calcium and parathyroid hormone (PTH) levels, lymph node yield, and complication rates.
Main Results:
- The nano-carbon suspension group showed significantly more stable postoperative calcium levels (Day 1: 2.22 vs 2.06 mmol/L; Week 1: 2.29 vs 2.22 mmol/L) and higher PTH levels.
- A greater median number of dissected lymph nodes (11.00 vs 7.00) and a lower rate of pathological parathyroid gland identification (6.5% vs 23.2%) were observed in the experimental group.
- Reduced incidence of postoperative numbness and twitching (4.7% vs 16.1%) and a lower 12-month recurrence rate (4.7% vs 12.5%) were noted with nano-carbon suspension.
Conclusions:
- Nano-carbon suspension significantly enhances parathyroid gland preservation during thyroidectomy and lymph node dissection for PTC.
- The use of nano-carbon suspension improves surgical precision, reduces specific postoperative complications, and potentially lowers recurrence rates.
- Nano-carbon suspension demonstrates potential for standard adoption in thyroid cancer surgery to optimize patient outcomes.
