White blood cell Indices to predict first trimester missed miscarriage

Area of Science:

• Obstetrics and Gynecology
• Hematology
• Reproductive Medicine

Background:

• Missed miscarriage is a pregnancy complication.
• Early identification of missed miscarriage is crucial for timely intervention.
• White blood cell (WBC) indices are being investigated as potential biomarkers.

Purpose of the Study:

• To investigate the relationship between WBC indices and missed miscarriage in the first trimester.
• To compare WBC profiles in ongoing pregnancies versus missed miscarriages.
• To assess the diagnostic accuracy of WBC ratios for missed miscarriage.

Main Methods:

• A diagnostic accuracy study involving 167 women in their first trimester.
• Participants were divided into an ongoing pregnancy group and a missed miscarriage group.
• Total and differential leukocyte counts, neutrophil-to-lymphocyte ratio (NLR), and monocyte-to-lymphocyte ratio (MLR) were compared.

Main Results:

• Lymphocyte count, NLR, and MLR differed significantly between groups (p<0.05).
• Mean WBC, neutrophil, and monocyte counts showed no significant difference.
• NLR and MLR demonstrated a fair ability to predict missed miscarriage within the first trimester (p<0.05).

Conclusions:

• No significant correlation was found between WBC count and gestational age.
• Reduced MLR and NLR levels can be utilized for cost-effective prediction of missed miscarriage.
• These WBC ratios show potential as early predictive markers for missed miscarriage.